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Adding a different reply-to address is a way to have responses to an email message sent to a different email address.
To enter a different reply-to address, add it to the field marked different reply-to in the campaign creation process. If you leave this field blank, replies will be sent to the email you entered in the 'From' field when creating your list.
Entering a different reply-to address is especially useful when you want replies to be sent to a group of people rather than one specific person, vice versa, or when you are sending on behalf of a third party.